Mechanisms of cell proliferation through primary cilium
نویسندگان
چکیده
منابع مشابه
Primary Cilium-Dependent Signaling Mechanisms
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell. The overall function of a cilium is therefore to act as a communica...
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The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in...
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Primary cilia are post-mitotic cellular organelles that are present in the vast majority of cell types in the human body. An extensive body of data gathered in recent years is demonstrating a crucial role for this organelle in a number of cellular processes that include mechano and chemo-sensation as well as the transduction of signaling cascades critical for the development and maintenance of ...
متن کاملTargeting of β-Arrestin2 to the Centrosome and Primary Cilium: Role in Cell Proliferation Control
BACKGROUND The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls important physiological processes. Specific sets of membrane proteins involved in sensing the extracellular milieu are concentrated within cilia, including G protein coupled receptors (GPCRs). Most GPCRs are regulated by beta-a...
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Linda Schneider,1 Christian A. Clement,1 Stefan C. Teilmann,2 Gregory J. Pazour,3 Else K. Hoffmann,1 Peter Satir,4 and Søren T. Christensen1,* 1Department of Biochemistry Institute for Molecular Biology and Physiology University of Copenhagen The August Krogh Building Universitetsparken 13 DK-2100 Copenhagen Ø Denmark 2Laboratory of Reproductive Biology Rigshospitalet DK-2100 Copenhagen Ø Denma...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2019
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.154.197